Major tumor regression after paclitaxel and carboplatin polychemotherapy in a patient with advanced penile cancer.

Abstract

Penile cancer is rare in Western countries. High-risk patients are considered for prophylactic inguinal lymphadenectomy. For advanced disease, a triplet drug regimen consisting of bleomycin, methotrexate, and cisplatin is the most active combination tested so far. A 62-year-old man with penile cancer underwent partial penile amputation but presented 10 months later with inguinal nodal metastasis. He received three cycles of paclitaxel/carboplatin with marked clinical and radiologic (computed tomography and positron emission tomography) tumor regression. Later, complete resection of the inguinal nodal metastasis was performed. The paclitaxel/carboplatin combination has potential activity in penile cancer. Positron emission tomography may be used for screening of nodal metastases.

• Authors: M Joerger, T Warzinek, B Klaeser, J T Kluckert, H-P Schmid, S Gillessen
• Journal: Urology (Urology) Vol. 63 Issue 4 Pg. 778-80 (Apr 2004) ISSN: 1527-9995 [Electronic] United States
• PMID: 15072904 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Fluorodeoxyglucose F18
• Carboplatin
• Paclitaxel

Topics

• Antineoplastic Agents, Phytogenic (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, pathology)
• Combined Modality Therapy
• Fluorodeoxyglucose F18
• Humans
• Lymph Node Excision (methods)
• Lymph Nodes (diagnostic imaging, pathology, surgery)
• Lymphatic Metastasis (diagnostic imaging, pathology)
• Male
• Middle Aged
• Paclitaxel (therapeutic use)
• Penile Neoplasms (drug therapy, pathology, surgery)
• Penis (surgery)
• Remission Induction (methods)
• Survival Analysis
• Tomography, Emission-Computed