HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Pulmonary edema related to administration of 15-methyl-prostaglandin F2alpha during a cesarean section].

Abstract
An 18-year-old woman pregnant at 37 weeks gestation and with a history of recurrent urinary tract infection was admitted with a clinical picture of pyelonephritis that responded favorably to antibiotic treatment. After 2 days, cervical ripening was induced with prostaglandin E2 gel and labor was induced with oxytocin. The patient requested epidural analgesia. Six hours after induction, cesarean delivery was indicated owing to risk of fetal distress. The operation was carried out under epidural anesthesia with 10 mL of 0.5% bupivacaine without a vasoconstrictor. After delivery, uterine atony was treated unsuccessfully with oxytocin and methylergometrine maleate; the obstetrician then gave an intramyometrial injection of 0.25 mg of 15-methyl-prostaglandin F2alpha (PGF2alpha). After 5 minutes, SpO2 fell to 89%, accompanied by dyspnea and sinus tachycardia of 130-140 beats/min, with normal cardiorespiratory sounds. The patient was transferred to the postoperative recovery unit, where a chest radiograph led to a diagnosis of acute pulmonary edema. Treatment to reduce edema was successful. PGF2alpha and its analogs are useful for treating uterine atony that does not respond to other drugs, but side effects are not unknown. Caution in prescribing PGF2alpha and care in monitoring the patient's reaction are therefore recommended during and after anesthesia. Unnecessary overhydration should be avoided.
AuthorsM R Rodríguez de la Torre, J I Gallego Alonso, M Gil Fernández
JournalRevista espanola de anestesiologia y reanimacion (Rev Esp Anestesiol Reanim) Vol. 51 Issue 2 Pg. 104-7 (Feb 2004) ISSN: 0034-9356 [Print] Spain
Vernacular TitleEdema pulmonar en una cesárea relacionado con la administración de 15-metil prostaglandina F2alpha.
PMID15072404 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Oxytocics
  • Carboprost
Topics
  • Adolescent
  • Carboprost (adverse effects)
  • Cesarean Section
  • Female
  • Humans
  • Intraoperative Complications (chemically induced)
  • Oxytocics (adverse effects)
  • Pregnancy
  • Pulmonary Edema (chemically induced)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: