Effect of ficus relegiosa on blood glucose and total lipid levels of normal and alloxan diabetic rabbits.
|
| Abstract | BACKGROUND: The present study was planned to observe the hypoglycemic effect of the 'Ficus relegiosa', a traditional medicinal plant. This study was performed to study the possible role of indigenous medicinal plants in the treatment of Diabetes mellitus (type-2) METHODS: Normal rabbits were divided into 5 groups (1-5) of six animals each. Group I served as control and received 15 ml of water only. Group 2 received tolbutamide 500-mg/Kg body weight. Group 3-5 received the extract of Ficus relegiosa dissolved in 15 ml of water in doses of 200 mg/Kg. 250 mg/Kg and 300 mg/Kg body weight respectively. The diabetic rabbits were also divided in 5 groups on the same pattern. The blood glucose and total lipid levels were estimated before and 1, 2, 3 and 4 hours after the administration of the extract. RESULTS: The extract exerted a significant (P < 0.05) hypoglycemic effect in normal rabbits, which was however short lived. The hypoglycemic effect was not significant (P > 0.05) in alloxan treated rabbits. The extract had no significant effect (P > 0.05) on total lipid levels in normal as well as in alloxan-treated diabetic rabbits. The doses used did not show acute toxicity or result in behavioral changes. CONCLUSION: From this study it may be concluded that the extract acts by initiating the release of insulin by pancreatic beta cells of normal rabbits.
|
|---|---|
| Authors | Noreen Wadood, Abdul Wadood, Mohammed Nisar |
| Journal | Journal of Ayub Medical College, Abbottabad : JAMC (J Ayub Med Coll Abbottabad) 2003 Oct-Dec Vol. 15 Issue 4 Pg. 40-2 ISSN: 1025-9589 [Print] Pakistan |
| PMID | 15067832 (Publication Type: Journal Article) |
| Chemical References |
|
| Topics |
|
Join CureHunter, for free Research Interface BASIC access!
Realize the full power of the drug-disease research graph!