HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The impact of maternal plasma volume expansion and antihypertensive treatment with intravenous dihydralazine on fetal and maternal hemodynamics during pre-eclampsia: a clinical, echo-Doppler and viscometric study.

AbstractOBJECTIVES:
To establish the effects of plasma volume expansion (PVE) followed by intravenous dihydralazine (DH) administration on maternal whole blood viscosity (WBV) and hematocrit, uteroplacental and fetoplacental downstream impedance and umbilical venous (UV) volume flow in pre-eclampsia.
METHODS:
In 13 pre-eclamptic women maternal and fetal hemodynamics were established by means of combined measurement of maternal arterial blood pressure (BP), WBV, hematocrit and uterine artery (UtA) resistance index (RI) in addition to umbilical artery (UA) pulsatility index (PI) and UV volume flow obtained from UV vessel area and UV time-averaged flow velocity. In each woman all parameters were measured four times at baseline, after PVE, after DH and 24 h after the start of treatment.
RESULTS:
Maternal diastolic BP, hematocrit and WBV display a significant reduction after PVE. In the fetus UA PI decreases significantly whereas a significant increase in UV cross-sectional area was detected. After maternal DH administration, arterial systolic and diastolic BP and UA PI show a significant decrease compared with the measurements following PVE. At 24 h, only maternal systolic and diastolic BP display a significant further decrease. No significant changes were established for the UtA RI, UV time-averaged velocity and UV volume flow during the entire study period.
CONCLUSIONS:
During pre-eclampsia, maternal PVE followed by DH administration results in a significant reduction in maternal diastolic BP, maternal hematocrit and WBV. Maternal PVE is associated with a significant increase in UV cross-sectional area and a non-significant rise of 11% in UV volume flow. Maternal DH administration does not result in any change in UV cross-sectional area. However, UA PI decreases significantly after both PVE and DH treatment.
AuthorsS M E Boito, P C Struijk, G A M Pop, W Visser, E A P Steegers, J W Wladimiroff
JournalUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (Ultrasound Obstet Gynecol) Vol. 23 Issue 4 Pg. 327-32 (Apr 2004) ISSN: 0960-7692 [Print] England
PMID15065180 (Publication Type: Journal Article)
CopyrightCopyright 2004 ISUOG.
Chemical References
  • Antihypertensive Agents
  • Dihydralazine
Topics
  • Antihypertensive Agents (therapeutic use)
  • Blood Pressure (physiology)
  • Dihydralazine (therapeutic use)
  • Echocardiography, Doppler (methods)
  • Female
  • Gestational Age
  • Hematocrit
  • Humans
  • Placental Circulation (physiology)
  • Plasma Volume (physiology)
  • Pre-Eclampsia (drug therapy, physiopathology, therapy)
  • Pregnancy
  • Pulsatile Flow (physiology)
  • Umbilical Arteries (physiopathology)
  • Umbilical Veins (physiopathology)
  • Vascular Resistance (physiology)
  • Viscosity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: