[Solitary bone plasmocytoma: treatment and outcome features].

Abstract

PURPOSE:

- To describe natural history of solitary bone plasmocytomas (SBO) after treatment.

PATIENTS AND METHODS:

- Between 1975 and 1998, we retrospectively identified 13 patients with SBO treated in the department of radiotherapy at Salah-Azaïz institute of Tunis. To be included in this study, three criteria were needed: histologic confirmation and only one bone lesion without medullary infiltration (or less than 10%). Mean age was 43 years (22-64) with sex-ratio of 3,3. Tumor sites were vertebra (6), flat bones (6) and tibia (1). Megavoltage radiotherapy was given to all patients, associated to surgery in eight cases (5 excisions and 3 laminectomies) and to chemotherapy in three.

RESULTS:

- With a mean follow-up of 63 months, two local failures were noted at 24 and 48 months. Two patients developed multifocal lesions and one patient had an extramedullary lesion. Multiple myeloma occurred in four patients (30%) after a median follow-up 3,5 years. Unfavorable outcome could not be predicted by age, gender or site of disease but by myeloma protein.

CONCLUSION:

- Radiotherapy is an effective local treatment for solitary bone plasmocytoma. Prospective studies are needed to better define predictive parameters of unfavourable outcome and indications of combined chemotherapy.

• Authors: L Kochbati, N Kédidi Ben Romdhane, K Mrad, C Nasr, D E Ben Salah, K Ben Romdhane, M Maalej
• Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique (Cancer Radiother) Vol. 8 Issue 2 Pg. 70-4 (Apr 2004) ISSN: 1278-3218 [Print] France
• PMID: 15063873 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cobalt Radioisotopes

Topics

• Adult
• Biopsy
• Bone Neoplasms (drug therapy, pathology, radiotherapy, surgery)
• Cobalt Radioisotopes (therapeutic use)
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Humans
• Laminectomy
• Male
• Middle Aged
• Multiple Myeloma (etiology)
• Plasmacytoma (drug therapy, pathology, radiotherapy, surgery)
• Radioisotope Teletherapy
• Radiotherapy, High-Energy
• Retrospective Studies
• Spinal Neoplasms (drug therapy, pathology, radiotherapy, surgery)
• Tibia (pathology)
• Time Factors
• Treatment Outcome