Abstract |
Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX ( PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA- PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA- PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635+/-5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm(2); light exposure dose, 100 J/cm(2)) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA- PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA- PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA- PDT with fractionated irradiations by an LED red light at 635+/-5 nm is an effective and successful treatment modality for OVH.
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Authors | Hsin-Ming Chen, Chin-Tin Chen, Hsiang Yang, Mark Yen-Ping Kuo, Ying-Shiung Kuo, Wan-Hong Lan, Yi-Ping Wang, Tsuimin Tsai, Chun-Pin Chiang |
Journal | Oral oncology
(Oral Oncol)
Vol. 40
Issue 6
Pg. 630-7
(Jul 2004)
ISSN: 1368-8375 [Print] England |
PMID | 15063392
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Adult
- Aminolevulinic Acid
(administration & dosage)
- Humans
- Hyperplasia
- Male
- Middle Aged
- Mouth Diseases
(drug therapy, pathology)
- Mouth Neoplasms
(drug therapy, pathology)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage)
- Precancerous Conditions
(drug therapy, pathology)
- Spectrometry, Fluorescence
(methods)
- Treatment Outcome
- Warts
(drug therapy, pathology)
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