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Successful treatment of oral verrucous hyperplasia with topical 5-aminolevulinic acid-mediated photodynamic therapy.

Abstract
Previous studies have shown a selective accumulation of 5-aminolevulinic acid (ALA)-derived protoporphrin IX (PpIX) in oral premalignant and malignant tissues. This provides a biologic rationale for the clinical use of ALA-mediated PDT (ALA-PDT) for oral premalignant and malignant lesions. In this study, five patients with oral verrucous hyperplasia (OVH) were treated with a new protocol of ALA-PDT composed of multiple 3-min irradiations with a light emitting diode (LED) red light at 635+/-5 nm separated with several 3-min rests for a total of 1000 s (fluence rate, 100 mW/cm(2); light exposure dose, 100 J/cm(2)) after topical application of 20% ALA for 1.5 or 2 h. Topical ALA-PDT was repeated once a week until the complete regression of the lesion. Complete regression of all OVH lesions was observed after 1-3 treatments (average, 2 treatments) of topical ALA-PDT. At an average follow-up of 5.6 months (range, 3-11 months), all the five OVH patients were free of tumor recurrence. We conclude that topical ALA-PDT with fractionated irradiations by an LED red light at 635+/-5 nm is an effective and successful treatment modality for OVH.
AuthorsHsin-Ming Chen, Chin-Tin Chen, Hsiang Yang, Mark Yen-Ping Kuo, Ying-Shiung Kuo, Wan-Hong Lan, Yi-Ping Wang, Tsuimin Tsai, Chun-Pin Chiang
JournalOral oncology (Oral Oncol) Vol. 40 Issue 6 Pg. 630-7 (Jul 2004) ISSN: 1368-8375 [Print] England
PMID15063392 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Photosensitizing Agents
  • Aminolevulinic Acid
Topics
  • Adult
  • Aminolevulinic Acid (administration & dosage)
  • Humans
  • Hyperplasia
  • Male
  • Middle Aged
  • Mouth Diseases (drug therapy, pathology)
  • Mouth Neoplasms (drug therapy, pathology)
  • Photochemotherapy (methods)
  • Photosensitizing Agents (administration & dosage)
  • Precancerous Conditions (drug therapy, pathology)
  • Spectrometry, Fluorescence (methods)
  • Treatment Outcome
  • Warts (drug therapy, pathology)

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