Abstract |
Vacuolar-type H+- adenosine triphosphatase (V- ATPase) is one of the most fundamental enzymes in nature. V- ATPases are responsible for the regulation of proton concentration in the intracellular acidic compartments. It has similar structure with the mitochondrial F0F1-ATP synthase (F- ATPase). dagger The V- ATPases are composed of multiple subunits and have various physiological functions, including membrane and organelle protein sorting, neurotransmitter uptake, cellular degradative processes, and cytosolic pH regulation. The V- ATPases have been involved in multidrug resistance. Recently, plasma membrane V- ATPases have been involved in regulation of extracellular acidity, essential for cellular invasiveness and proliferation in tumor metastasis. The current knowledge regarding the structure and function of V- ATPase and its role in cancer biology is discussed.
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Authors | Souad R Sennoune, Defeng Luo, Raul Martínez-Zaguilán |
Journal | Cell biochemistry and biophysics
(Cell Biochem Biophys)
Vol. 40
Issue 2
Pg. 185-206
( 2004)
ISSN: 1085-9195 [Print] United States |
PMID | 15054222
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Biomarkers, Tumor
- Vacuolar Proton-Translocating ATPases
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Topics |
- Animals
- Apoptosis
- Biomarkers, Tumor
(metabolism)
- Cell Membrane
(metabolism)
- Cell Movement
- Humans
- Neoplasm Invasiveness
- Neoplasms
(enzymology, pathology)
- Vacuolar Proton-Translocating ATPases
(metabolism)
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