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Efficacy of dapsone with pyrimethamine (Maloprim) for malaria prophylaxis in Maputo, Mozambique.

Abstract
In a randomized controlled study of malaria prophylaxis, dapsone-pyrimethamine at a weekly dosage of dapsone 50-100 mg with pyrimethamine 6.25-12.5 mg or placebo was administered to 166 school children for 17 weeks. Fortnightly parasitological controls revealed 28 infections in the placebo group and none in the dapsone-pyrimethamine group. It is concluded that weekly dapsone-pyrimethamine is effective for the prophylaxis of falciparum malaria in Mozambique.
AuthorsJ Pividal, V Viktinski, E Streat, A Schapira
JournalEast African medical journal (East Afr Med J) Vol. 69 Issue 6 Pg. 303-5 (Jun 1992) ISSN: 0012-835X [Print] Kenya
PMID1505413 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dapsone
  • Pyrimethamine
Topics
  • Child
  • Dapsone (administration & dosage, therapeutic use)
  • Drug Therapy, Combination
  • Humans
  • Malaria, Falciparum (parasitology, prevention & control)
  • Mozambique
  • Pyrimethamine (administration & dosage, therapeutic use)

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