HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A pilot study of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices in humans.

AbstractBACKGROUND:
N-butyl cyanoacrylate injection has been shown to be effective and safe for the endoscopic treatment of gastric varices. N-butyl cyanoacrylate is not available in the United States, but use of a similar agent, 2-octyl cyanoacrylate, recently was approved for skin closure. This pilot study prospectively evaluated the efficacy and safety of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices.
METHODS:
Twenty-five patients with large gastric fundal varices with either stigmata of recent hemorrhage, a history of bleeding, or high-risk varices underwent intravariceal injection of undiluted 2-octyl cyanoacrylate. The end points for this study were cessation of active bleeding, successful obliteration of visible varices, and prevention of bleeding.
RESULTS:
Within 2 weeks of treatment, 52% of patients had a history of significant variceal bleeding, and 12% had active gastric variceal bleeding at the time of injection. The rate of immediate hemostasis was 100%. Gastric variceal bleeding recurred in 4% of patients (mean follow-up 11 months). The overall mortality rate was 12%; the bleeding-related mortality rate was 4%.
CONCLUSIONS:
Injection of 2-octyl cyanoacrylate appears to be efficacious and safe for both prevention and control of gastric variceal hemorrhage. Larger studies are required to further establish the use of 2-octyl cyanoacrylate for treatment of gastric fundal varices.
AuthorsDaniel S Rengstorff, Kenneth F Binmoeller
JournalGastrointestinal endoscopy (Gastrointest Endosc) Vol. 59 Issue 4 Pg. 553-8 (Apr 2004) ISSN: 0016-5107 [Print] United States
PMID15044898 (Publication Type: Journal Article)
Chemical References
  • Cyanoacrylates
  • Tissue Adhesives
  • octyl 2-cyanoacrylate
Topics
  • Aged
  • Aged, 80 and over
  • Cyanoacrylates (administration & dosage)
  • Embolization, Therapeutic (methods)
  • Endoscopy, Gastrointestinal
  • Esophageal and Gastric Varices (diagnosis, therapy)
  • Female
  • Gastric Fundus
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Sclerotherapy (methods)
  • Tissue Adhesives (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: