Abstract | AIM: To evaluate hepatic reserve function by investigating the change of functional hepatic flow and total hepatic flow in cirrhotic patients with portal hypertension. METHODS: HPLC method was employed for the determination of concentration of D- sorbitol in human plasma and urine. The functional hepatic flow (FHF) and total hepatic flow (THF) were determined by means of modified hepatic clearance of D- sorbitol combined with duplex doppler color sonography in 20 patients with cirrhosis and 10 healthy volunteers. RESULTS: FHF, evaluated by means of the D- sorbitol clearance, was significantly reduced in patients with cirrhosis in comparison to controls (764.74+/-167.91 vs 1195.04+/-242.97 mL/min, P<0.01). While THF was significantly increased in patients with cirrhosis in comparison to controls (1605.23+/-279.99 vs 1256.12+/-198.34 mL/min, P<0.01). Portal blood flow and hepatic artery flow all were increased in cirrhosis compared to controls (P<0.05 and P<0.01). D- sorbitol total clearance was significantly reduced in cirrhosis compared to control (P<0.01), while D- sorbitol renal clearance was significantly increased in cirrhosis (P<0.05). In controls FHF was similar to THF (1195.05+/-242.97 vs 1256.12+/-198.34 mL/min, P=0.636), while FHF was significantly reduced compared with THF in cirrhosis (764.74+/-167.91 vs 1605.23+/-279.99 mL/min, P<0.01). CONCLUSION: Our method that combined modified hepatic clearance of D- sorbitol with duplex doppler color sonography is effective in the measurement of FHF and THF. FHF can be used to estimate hepatic reserve function.
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Authors | Zheng Pan, Xing-Jiang Wu, Jie-Shou Li, Fang-Nan Liu, Wei-Su Li, Jian-Ming Han |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 10
Issue 6
Pg. 915-8
(Mar 15 2004)
ISSN: 1007-9327 [Print] United States |
PMID | 15040046
(Publication Type: Journal Article)
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Chemical References |
- Indicators and Reagents
- Sorbitol
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Topics |
- Adult
- Aged
- Case-Control Studies
- Female
- Hepatic Artery
(physiopathology)
- Humans
- Hypertension, Portal
(complications)
- Indicators and Reagents
(pharmacokinetics)
- Kidney
(metabolism)
- Liver Circulation
- Liver Cirrhosis
(etiology, physiopathology)
- Male
- Middle Aged
- Portal System
(physiopathology)
- Sorbitol
(pharmacokinetics)
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