An evaluation of Ki-67 and PCNA expression in conjunctival and eyelid tumours.

Abstract

The aim of our study was an evaluation of the expression of cell proliferation markers (PCNA and Ki-67) in conjunctival and eyelid papillomas and squamous and basal cell cancers. A series of 9 cases of squamous cell cancer (SCC), 15 cases of basal cell cancer (BCC) and 43 cases of squamous cell papilloma (SCP) were assessed using the immunohistochemical method with monoclonal antibodies. PCNA overexpression was observed in 100% of SCP, in 88.8% of SCC and in 100% of BCC cases. Ki-67 overexpression was seen in 32.5% of cases of SCP, in 22.2% of SCC and in 66.6% of BCC. The results showed that an evaluation of Ki-67 expression is the most valuable cell proliferation marker.

• Authors: Joanna Reszeć, Luiza Kańczuga-Koda, Mariola Sulkowska, Mariusz Koda, Jacek Cylwik, Małgorzata Barwijuk-Machała, Stanisław Sulkowski
• Journal: Folia morphologica (Folia Morphol (Warsz)) Vol. 63 Issue 1 Pg. 95-8 (Feb 2004) ISSN: 0015-5659 [Print] Poland
• PMID: 15039910 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ki-67 Antigen
• Proliferating Cell Nuclear Antigen

Topics

• Carcinoma, Basal Cell (metabolism, pathology)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Conjunctival Neoplasms (metabolism, pathology)
• Eye Neoplasms (metabolism, pathology)
• Eyelid Neoplasms (metabolism, pathology)
• Humans
• Ki-67 Antigen (metabolism)
• Papilloma (metabolism, pathology)
• Proliferating Cell Nuclear Antigen (metabolism)