Reversible diffusion MRI abnormalities and transient mutism after liver transplantation.

Abstract

Transient mutism was observed in a liver transplant patient under immunosuppressant therapy with cyclosporine A and antifungal prophylaxis with amphotericin B. Fluid-attenuated inversion recovery and diffusion-weighted images revealed reversible bilateral symmetric hyperintensity located in the frontal motor cortex and corticospinal tracts. These MRI abnormalities may be caused by acute edema, possibly a combination of cytotoxic and vasogenic edema, which resolved with a prompt change in therapy.

• Authors: F Bianco, F Fattapposta, N Locuratolo, A Pierallini, M Rossi, F Ruberto, L Bozzao
• Journal: Neurology (Neurology) Vol. 62 Issue 6 Pg. 981-3 (Mar 23 2004) ISSN: 1526-632X [Electronic] United States
• PMID: 15037706 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Diffusion Magnetic Resonance Imaging
• Frontal Lobe (pathology)
• Hepatitis C (complications)
• Humans
• Immunosuppressive Agents (adverse effects)
• Liver Cirrhosis (surgery, virology)
• Liver Transplantation (adverse effects)
• Male
• Middle Aged
• Mutism (diagnosis, etiology)
• Pyramidal Tracts (pathology)
• Recovery of Function