Early prenatal diagnosis and therapy of fetal hypothyroid goiter.

We report a case of early diagnosis of iodide-induced fetal hypothyroidism at 22 weeks of gestation, confirmed at 29 weeks by cordocentesis and successfully treated intra-amniotically. The ultrasonographic feature was the presence of two echogenic masses in the fetal neck; polyhydramnios was absent. Mild hypothyroidism was diagnosed based on fetal serum obtained by percutaneous umbilical blood sampling at 29 weeks of gestation. The persistence of fetal hypothyroidism in spite of maternal thyroid improvement was confirmed by a second cordocentesis at 35 weeks of gestation, and a single injection of intra-amniotic levothyroxine (250 micrograms) was performed. The serial ultrasonographic examinations showed disappearance of the fetal goiter. A healthy female baby (3,630 g) was delivered at term. At birth, the thyroid gland was not enlarged, and neonatal thyroid hormones were within the normal range. This case suggests that cordocentesis is a reliable method to assess the fetal thyroid status; moreover a single injection of intra-amniotic thyroxine was effective in treating fetal hypothyroid goiter.
AuthorsG Noia, M De Santis, A Tocci, M L Maussier, G D'Errico, A Bianchi, C Romagnoli, L Masini, A Caruso, S Mancuso
JournalFetal diagnosis and therapy (Fetal Diagn Ther) Vol. 7 Issue 2 Pg. 138-43 ( 1992) ISSN: 1015-3837 [Print] SWITZERLAND
PMID1503649 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Thyroid Hormones
  • Thyroxine
  • Adult
  • Amniotic Fluid
  • Congenital Hypothyroidism
  • Female
  • Fetal Diseases (blood, diagnosis, drug therapy)
  • Goiter (congenital, diagnosis, drug therapy)
  • Humans
  • Hypothyroidism (diagnosis, drug therapy)
  • Infant, Newborn
  • Pregnancy
  • Prenatal Diagnosis
  • Thyroid Hormones (blood)
  • Thyroxine (administration & dosage, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: