[Recurrent polyomavirus infections in kidney transplants (BK virus nephropathy)].

Abstract

BK-virus nephropathy was recently recognised as a new complication that affects renal allografts and causes dysfunction. We report a case of a recipient of simultaneous kidney-pancreas allografts. Fourteen months after the transplant, the renal allograft became dysfunctional with elevation of serum creatinine level. The diagnosis of BK-virus nephropathy was established by needle renal biopsy with immunohistochemical detection of human polyoma virus. Immunosuppressive therapy was reduced but progressive dysfunction developed and the patient had to undergo a renal retransplantation 11 months after the diagnosis of the infection. Due to repeated renal dysfunction, needle biopsy was performed, and the diagnosis of repeated BK-virus nephropathy was established six months after the retransplantation. The pancreas allograft has functioned well for the entire period.

• Authors: E Honsová, A Lodererová, T Havrdová, L Voska, P Boucek
• Journal: Ceskoslovenska patologie (Cesk Patol) Vol. 40 Issue 1 Pg. 25-8 (Jan 2004) ISSN: 1210-7875 [Print] Czech Republic
• Vernacular Title: Opakovaná polyomavirová infekce transplantované ledviny (BK virus nefropatie).
• PMID: 15035058 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• BK Virus
• Biopsy, Needle
• Humans
• Immunocompromised Host
• Kidney (pathology)
• Kidney Diseases (diagnosis, pathology)
• Kidney Transplantation (immunology)
• Male
• Polyomavirus Infections (diagnosis, pathology)
• Recurrence
• Reoperation
• Tumor Virus Infections (diagnosis, pathology)