Crimean-Congo hemorrhagic fever virus genome L RNA segment and encoded protein.

Sequence analysis of the L RNA genome segment and predicted encoded L polymerase protein of Crimean-Congo hemorrhagic fever (CCHF) virus (genus Nairovirus, family Bunyaviridae) demonstrates that they are approximately twice the size of those found in viruses of other bunyavirus genera. The CCHF virus L segment and encoded protein (12,164 nucleotides and 3944 amino acids, respectively) are similar in size and sequence to those of the nairovirus Dugbe virus (12,255/62% and 4036/62% nucleotide and amino acid length/identity, respectively). The identification of an ovarian tumor (OTU)-like protease motif in the L protein amino termini of the nairoviruses Dugbe, CCHF, and Nairobi sheep disease (NSD) indicates these proteins are members of the recently described OTU-like protease family and suggests that these large proteins may be polyproteins that are autoproteolytically cleaved or involved in deubiquitination.
AuthorsJessica E Honig, Jane C Osborne, Stuart T Nichol
JournalVirology (Virology) Vol. 321 Issue 1 Pg. 29-35 (Mar 30 2004) ISSN: 0042-6822 [Print] United States
PMID15033562 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • DNA-Directed RNA Polymerases
  • Amino Acid Motifs (genetics)
  • Amino Acid Sequence
  • DNA-Directed RNA Polymerases (genetics)
  • Genome, Viral
  • Hemorrhagic Fever Virus, Crimean-Congo (chemistry, enzymology, genetics)
  • Molecular Sequence Data
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment

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