Abstract | BACKGROUND: AIM: METHODS: RESULTS: Thirty-three subjects were heterozygous for the -493 G/T substitution. These patients had significantly lower LDL cholesterol (3.0 +/- 0.2 vs. 3.5 +/- 0.1 mmol/l, p < 0.02). In the postprandial period, they had higher levels of apoB48 in the VLDL fraction (4 h, 7.0 +/- 1.4 vs. 2.9 +/- 0.4 microg/ml plasma, p < 0.002; 6 h, 6.4 +/- 1.0 vs. 3.5 +/- 0.5 microg/ml plasma, p < 0.05). In the VLDL fraction there was significantly less cholesterol at 4 and 6 h (p < 0.05). The -400 A/T substitution gave very similar lipoprotein results, but there was significant linkage dysequilibrium between the two polymorphisms. No association was found between the -164 T/C polymorphism and either plasma lipids or the postprandial lipid profile. ApoE genotype was also examined, but did not influence the above results. DISCUSSION: The common -493 G/T MTP polymorphism is associated with changes in VLDL and LDL in Type 2 diabetic patients. The importance of the changes in apoB48-containing small particles requires further investigation. The significantly lower LDL cholesterol suggests that this polymorphism may confer protection against atherosclerosis in type 2 diabetes.
|
Authors | C Phillips, K Mullan, D Owens, G H Tomkin |
Journal | QJM : monthly journal of the Association of Physicians
(QJM)
Vol. 97
Issue 4
Pg. 211-8
(Apr 2004)
ISSN: 1460-2725 [Print] England |
PMID | 15028851
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Carrier Proteins
- Chylomicrons
- Lipoproteins, VLDL
- microsomal triglyceride transfer protein
- Cholesterol
|
Topics |
- Aged
- Carrier Proteins
(genetics)
- Cholesterol
(blood)
- Chylomicrons
(blood)
- Diabetes Mellitus, Type 2
(blood, genetics)
- Female
- Humans
- Lipoproteins, VLDL
(blood, genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
|