Radical cystectomy for invasive bladder cancer: results of multi-institutional pooled analysis.

Abstract

BACKGROUND:

We report the outcome of radical cystectomy for patients with invasive bladder cancer, who did not have regional lymph node or distant metastases, at 21 hospitals.

METHODS:

Retrospective, non-randomized, multi-institutional pooled data were analyzed to evaluate outcomes of patients who received radical cystectomy. Between 1991 and 1995, 518 patients with invasive bladder cancer were treated with radical cystectomy at 21 hospitals. Of these, 250 patients (48.3%) received some type of neoadjuvant and/or adjuvant therapy depending on the treatment policy of each hospital.

RESULTS:

The median follow-up period was 4.4 years, ranging from 0.1 to 11.4 years. The 5-year overall survival rate was 58% for all 518 patients. The 5-year overall survival rates for patients with clinical T2N0M0, T3N0M0 and T4N0M0 were 67%, 52% and 38%, respectively. The patients with pT1 or lower stage, pT2, pT3 and pT4 disease without lymph node metastasis had 5-year overall survivals of 81%, 74%, 47% and 38%, respectively. The patients who were node positive had the worst prognosis, with a 30% overall survival rate at 5 years. Neoadjuvant or adjuvant chemotherapy did not provide a significant survival advantage, although adjuvant chemotherapy improved the 5-year overall survival in patients with pathologically proven lymph node metastasis.

CONCLUSIONS:

The current retrospective study showed that radical cystectomy provided an overall survival equivalent to studies reported previously, but surgery alone had no more potential to prolong survival of patients with invasive cancer. Therefore, a large-scale randomized study on adjuvant treatment as well as development of new strategies will be needed to improve the outcome for patients with invasive bladder cancer.

• Authors: Atsushi Takahashi, Taiji Tsukamoto, Ken-ichi Tobisu, Nobuo Shinohara, Kazunari Sato, Yoshihiko Tomita, Shu-ichi Komatsubara, Osamu Nishizawa, Tatsuo Igarashi, Hiroyuki Fujimoto, Hayakazu Nakazawa, Hideki Komatsu, Yoshiki Sugimura, Yoshinari Ono, Masao Kuroda, Osamu Ogawa, Yoshihiko Hirao, Tadashi Hayashi, Tomoyasu Tsushima, Yoshiyuki Kakehi, Yoichi Arai, Sho-ichi Ueda, Masayuki Nakagawa
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 34 Issue 1 Pg. 14-9 (Jan 2004) ISSN: 0368-2811 [Print] England
• PMID: 15020658 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Aged, 80 and over
• Cystectomy
• Female
• Humans
• Lymph Node Excision
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Invasiveness
• Neoplasm Staging
• Prognosis
• Retrospective Studies
• Survival Rate
• Time Factors
• Treatment Outcome
• Urinary Bladder Neoplasms (mortality, pathology, surgery)