In view of comparatively-high incidence of papillary, well or moderately-well differentiated,
transitional cell carcinomas in urology, and of frequent recurrence of
carcinomas after appropriate procedures, we have undertaken the correlative study on urinary cytology with cystoscopy, pathology and the amount of
fibrinogen and degradation products of
fibrinogen and
fibrin (
FDP). Cytopathologically, 191 cases were confirmed histologically for
cancers out of 442 cases studied cytologically; among these 442 classes IV and V were found in 136 cases, and 99 of 136 cases (72.8%) had
cancers. Admittedly, we were unable to suspect
tumors cytologically in 24.5% of the cases. As to histological gradings and cytology, 48.7% of classes I and II in well differentiated were found against 52.9% and 57.1% of classes IV and V in moderately-well and poorly differentiated
carcinomas, respectively. Urinary
FDP assay was quite promising; out of 19 cases with both positive cytology and
FDP, 18 (94.7% had
carcinomas histologically, whereas 12 of 56 cases (21.4%) with both negative cytology and
FDP bore
cancers. Subsequently, several proposals for improving the diagnostic accuracy were discussed. We concluded the importance of accumulating more cases by combining several diagnostic procedures, especially among well and moderately-well differentiated
carcinomas.