Update on the mechanism of action of bimatoprost: a review and discussion of new evidence.

Abstract	Bimatoprost is a pharmacologically unique and highly efficacious anti-glaucoma agent. It appears to mimic the activity of the prostamides, which are biosynthesized from the natural endocannabinoid anandamide by the enzyme cyclo-oxygenase 2 (COX-2). Bimatoprost has also been suggested to lower intraocular pressure by behaving as a prodrug or, alternatively, by stimulating FP receptors directly. These three distinctly different hypotheses for the mechanism of bimatoprost activity are discussed in the light of current evidence.
Authors	Achim H-P Krauss, David F Woodward
Journal	Survey of ophthalmology (Surv Ophthalmol) Vol. 49 Suppl 1 Pg. S5-11 (Mar 2004) ISSN: 0039-6257 [Print] United States
PMID	15016556 (Publication Type: Journal Article, Review)
Chemical References	Amides Antihypertensive Agents Lipids Prodrugs Receptors, Prostaglandin prostaglandin F2alpha receptor Cloprostenol Bimatoprost
Topics	Amides Antihypertensive Agents (pharmacokinetics, pharmacology) Bimatoprost Cloprostenol (analogs & derivatives) Glaucoma (drug therapy, metabolism) Humans Intraocular Pressure (drug effects) Lipids (pharmacokinetics, pharmacology) Prodrugs (pharmacokinetics, pharmacology) Receptors, Prostaglandin (metabolism)

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