Intravitreal triamcinolone in the treatment of serous retinal detachment in Vogt-Koyanagi-Harada syndrome.

Abstract

PURPOSE:

To report the use of intravitreal injection of triamcinolone acetonide during the acute phase of Vogt-Koyanagi-Harada disease.

DESIGN:

Prospective interventional case series.

METHODS:

Three eyes from two patients at the acute phase of Vogt-Koyanagi-Harada disease with serous retinal detachments were treated with a 4-mg intravitreal injection of triamcinolone acetonide. The following variables were evaluated: visual acuity, intraocular pressure, and height of the serous retinal detachment using optical coherence tomography.

RESULTS:

The optical coherence tomography images showed a marked decrease in the retinal detachment in the first week after the injection with subsequent return to normal retinal thickness in all eyes.

CONCLUSIONS:

Intravitreal triamcinolone acetonide provides short-term improvement in visual acuity and serous retinal detachments associated with Vogt-Koyanagi-Harada disease. These findings should be followed by future studies to evaluate long-term effects.

• Authors: Rafael E Andrade, Cristina Muccioli, Michel E Farah, Robert B Nussenblatt, Rubens Belfort Jr
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 137 Issue 3 Pg. 572-4 (Mar 2004) ISSN: 0002-9394 [Print] United States
• PMID: 15013890 (Publication Type: Case Reports, Journal Article)

Chemical References

• Glucocorticoids
• Triamcinolone Acetonide

Topics

• Acute Disease
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Injections
• Intraocular Pressure
• Middle Aged
• Prospective Studies
• Retinal Detachment (drug therapy, etiology, pathology)
• Tomography, Optical Coherence
• Triamcinolone Acetonide (therapeutic use)
• Uveomeningoencephalitic Syndrome (complications, drug therapy, pathology)
• Visual Acuity
• Vitreous Body