[99mTc]diphosphonate uptake and hemodynamics in experimental arthritis: effect of naproxen in the canine carrageenan injection model.

Abstract

The impact of naproxen treatment on juxta-articular hemodynamics and bone metabolism in experimental juvenile arthritis was studied in the articular carrageenan injection model. Unilateral gonarthritis was induced for 12 weeks in eight dogs receiving naproxen (dosage, 2 mg/kg) and eight controls. Regional blood flow was assessed by the microsphere method, plasma volume by the distribution space of [125I]fibrinogen, and bone metabolism by the 2-h uptake of [99mTc]diphosphonate ([99mTc]DPD). Synovial effusion was less prominent with naproxen treatment as judged by joint fluid volume and pressure. Naproxen reduced the arthritic capsular hyperemia, almost normalized a severe blood flow increase in patella and both juxta-articular epiphyses, ameliorated an expansion of plasma volume in the patella and the distal femoral epiphysis, and normalized an increased [99mTc]DPD uptake in subchondral femoral bone and the tibial cortex. Significantly increased arteriovenous shunting in the arthritic extremity was unaffected by naproxen. The study suggests that long-term cyclooxygenase inhibition offers protection against hemodynamic and metabolic changes in juxta-articular bone secondary to synovial inflammation.

• Authors: E S Hansen, S Z He, K Søballe, D Kjølseth, T B Henriksen, V E Hjortdal, C Bünger
• Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (J Orthop Res) Vol. 10 Issue 5 Pg. 647-56 (Sep 1992) ISSN: 0736-0266 [Print] United States
• PMID: 1500978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Diphosphonates
• Technetium Compounds
• Naproxen
• Technetium
• technetium Tc 99m diphosphonate
• Carrageenan

Topics

• Animals
• Arthritis (chemically induced, drug therapy, metabolism)
• Bone and Bones (blood supply, metabolism, physiology)
• Capillary Permeability (physiology)
• Carrageenan (administration & dosage, adverse effects)
• Diphosphonates (pharmacokinetics)
• Disease Models, Animal
• Dogs
• Growth Plate (blood supply, physiology)
• Hemodynamics (drug effects)
• Homeostasis
• Injections
• Microspheres
• Naproxen (pharmacology, therapeutic use)
• Regional Blood Flow
• Technetium (pharmacokinetics)
• Technetium Compounds