Abstract | BACKGROUND: Topical 5-fluorouracil (5-FU) is a standard treatment for Bowen's disease. However, its efficacy may be limited by the presence of stratum corneum. The Er:YAG laser has shown a dramatic enhancement effect on the delivery of 5-FU in vitro by ablation of the stratum corneum. The efficacy of laser-assisted delivery of 5-FU has not been tested in human. OBJECTIVE: METHODS: Three target lesions from a patient with multiple Bowen's disease were selected for a half-side comparison study. The Er:YAG laser was used to remove the cornified layer on one side of each lesion, followed by twice-daily application of 5-FU cream to both sides. Clinical and histologic responses were compared. RESULTS: Lesions pretreated with the Er:YAG laser showed more rapid clinical and histologic responses to topical 5-FU than those treated with 5-FU alone. Evaluation at 9 months after treatment showed no recurrences of lesions on both sides. CONCLUSIONS: Our preliminary study demonstrates that this Er:YAG laser-assisted modality is effective and shows accelerated clinical response and shortened treatment time compared with topical 5-FU as a single treatment.
|
Authors | Kuo-Hsien Wang, Jia-You Fang, Chung-Hong Hu, Woan-Ruoh Lee |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 30
Issue 3
Pg. 441-5
(Mar 2004)
ISSN: 1076-0512 [Print] United States |
PMID | 15008880
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antimetabolites, Antineoplastic
- Fluorouracil
|
Topics |
- Administration, Topical
- Antimetabolites, Antineoplastic
(administration & dosage)
- Bowen's Disease
(drug therapy, radiotherapy)
- Combined Modality Therapy
- Fluorouracil
(administration & dosage)
- Humans
- Laser Therapy
- Male
- Middle Aged
- Skin Neoplasms
(drug therapy, radiotherapy)
|