Abstract | OBJECTIVE: To evaluate the comparative efficacy and tolerability of naratriptan in the treatment of acute attacks of migraine. DESIGN: Meta-analysis of randomised controlled trials using a random effects model. SUBJECTS: A total of 4499 patients suffering from moderate or severe attacks of acute migraine reported in ten trials. MAIN OUTCOME MEASURES: Response rate ratios for headache relief, pain-free response and sustained relief (4-24 hours). Adverse events were estimated with the rate ratio (RR), risk difference and number needed to harm. RESULTS: Pooled RRs relative to placebo for pain-free response at 2 and 4 hours for naratriptan 2.5 mg were 2.52 (95% CI: 1.78-3.57) and 2.58 (1.99-3.35). Naratriptan 2.5 mg was more effective than naratriptan 1 mg; the corresponding RRs for pain-free response at 2 and 4 hours were 1.54 (95% CI: 1.28-1.86) and 1.35 (1.20-1.51). In contrast, naratriptan 2.5 mg was less effective in pain-free response than either rizatriptan 10 mg at 4 hours (RR: 0.68; 95% CI: 0.55-0.85) or sumatriptan 100 mg at 4 hours (RR: 0.79; 95% CI: 0.67-0.93). However, significantly fewer patients experienced adverse effects with naratriptan 2.5 mg than with rizatriptan 10 mg (RR: 0.73; 95% CI: 0.56-0.97) or sumatriptan 100 mg (RR: 0.68; 95% CI: 0.55-0.86). CONCLUSIONS:
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Authors | Darren M Ashcroft, David Millson |
Journal | Pharmacoepidemiology and drug safety
(Pharmacoepidemiol Drug Saf)
Vol. 13
Issue 2
Pg. 73-82
(Feb 2004)
ISSN: 1053-8569 [Print] England |
PMID | 14998068
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- Oxazolidinones
- Piperidines
- Serotonin Receptor Agonists
- Triazoles
- Tryptamines
- zolmitriptan
- rizatriptan
- Sumatriptan
- naratriptan
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Topics |
- Dose-Response Relationship, Drug
- Humans
- Indoles
(administration & dosage, adverse effects, therapeutic use)
- Migraine Disorders
(drug therapy)
- Oxazolidinones
(administration & dosage, adverse effects, therapeutic use)
- Piperidines
(administration & dosage, adverse effects, therapeutic use)
- Randomized Controlled Trials as Topic
- Serotonin Receptor Agonists
(administration & dosage, adverse effects, therapeutic use)
- Sumatriptan
(administration & dosage, adverse effects, therapeutic use)
- Triazoles
(administration & dosage, adverse effects, therapeutic use)
- Tryptamines
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