[Minimally invasive, safe treatment of the neurogenic bladder with botulinum-A-toxin in children with myelomeningocele].

Abstract

PURPOSE:

The efficacy and durability of botulinum-A toxin in the treatment of detrusor hyperreflexia in myelomeningocele (MMC) children was evaluated prospectively.

MATERIALS AND METHODS:

A total of 15 children (10 male and 5 female, mean age 5.8 years), all on clean intermittent catheterisation (CIC) due to MMC, were "non responders" to orally and intravesically administered anticholinergic medication. Pretreatment assessment included a videourodynamic evaluation, incontinence scoring and a mercaptoacetyltriglycine-3 renal scan. We injected from 10 U/kg up to a maximum of 360 U botulinum-A toxin at 25-40 sites of the detrusor, sparing the trigone. Follow-up was 24 months. All children had a urodynamic reevaluation with assessment of bladder capacity and incontinence score at 3, 9 and 12 months.

RESULTS:

Mean bladder reflex volume increased from 72.00 +/- 28.12 ml to 298 +/- 32.45 ml (p < 0.001). The maximal detrusor pressure decreased from 78.76 +/- 23.14 cm H(2)O to 42.76 +/- 24.34 cm H(2)O (p < 0.001). Maximal bladder capacity increased from 136.34 +/- 45.71 ml to 297.02 +/- 87.17 ml (p < 0.001). Detrusor compliance increased from 18.29 +/- 27.19 ml/cm H(2)O to 51.17 +/- 38.17 ml/mmH(2)O (p < 0.001). While 10 patients became completely dry between CIC, the remaining 2 patients improved from score 3 to 1. Results at 9 months were similar to the ones at 3 months. The mean efficacy and durability of the toxin was 10.5 months after the first intravesical injection.

CONCLUSIONS:

Botulinum-A toxin is a safe alternative in the management of detrusor hyperreflexia in MMC children. Preliminary results are promising concerning urodynamic parameters and continence.

• Authors: L Lusuardi, A Nader, M Koen, A Schrey, M Schindler, M Riccabona
• Journal: Aktuelle Urologie (Aktuelle Urol) Vol. 35 Issue 1 Pg. 49-53 (Feb 2004) ISSN: 0001-7868 [Print] Germany
• Vernacular Title: Minimalinvasive, sichere Behandlung der neurogenen Blase bei Myelomeningozelen-Kindern mit Botulinum-Toxin A.
• PMID: 14997415 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (administration & dosage)
• Child
• Child, Preschool
• Female
• Follow-Up Studies
• Humans
• Injections, Intramuscular
• Male
• Meningomyelocele (complications)
• Muscle Hypertonia (drug therapy)
• Prospective Studies
• Treatment Outcome
• Urinary Bladder, Neurogenic (drug therapy)
• Urodynamics (drug effects)