Differences in dihydropyrimidine dehydrogenase activities between gastric and colorectal cancer.
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| Abstract |
We studied the relation between clinicopathological factors and dihydropyrimidine dehydrogenase (DPD) activity in gastric and colorectal carcinomas. Specimens obtained by surgery from 27 gastric and 17 colorectal carcinomas and their normal mucosa were examined. The levels of DPD activity in the gastric carcinomas and their normal mucosa were significantly higher than those in colorectal carcinomas and their normal counterparts, respectively (both P's < 0.0001). The gastric carcinomas had significantly higher DPD activities than their normal mucosa (P = 0.028), but the colorectal carcinomas did not. Among the clinicopathological factors, which included invasion/metastatic status and staging, the only effect was that of the histological differences of gastric cancer on DPD activity. That is, the level of DPD activity of the histologically undifferentiated gastric carcinoma was significantly higher than that of the differentiated type. No prognostic predictive values of DPD were recognized in either gastric and colorectal cancer. In conclusion, the higher DPD activity in gastric cancer than colorectal cancer may be due to the higher DPD activity in the background mucosa of origin, and the higher population of undifferentiated type of histological classification, compared to the colorectal counterparts.
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| Authors | Bunzo Nakata, Kazuya Muguruma, Shigehito Yamagata, Kiyotaka Yukimoto, Kiyoshi Maeda, Yukio Nishiguchi, Masaichi Ohira, Yasuyuki Kato, Kosei Hirakawa |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 49 Issue 1 Pg. 60-4 (Jan 2004) ISSN: 0163-2116 [Print] United States |
| PMID | 14992436 (Publication Type: Evaluation Study, Journal Article) |
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