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Relationship of gastric Helicobacter pylori infection to Barrett's esophagus and gastro-esophageal reflux disease in Chinese.

AbstractAIM:
To evaluate the relationship of Helicobacter pylori infection to reflux esophagitis (RE), Barrett's esophagus (BE) and gastric intestinal metaplasia (IM).
METHODS:
RE, BE and gastric IM were determined by upper endoscopy. Patients were divided into 2 groups; those with squamocolumnar junction (SCJ) beyond gastroesophageal junction (GEJ) > =3 cm (group A), and those with SCJ beyond GEJ <3 cm (group B). Biopsy specimens were obtained endoscopically from just below the SCJ, gastric antrum along the greater and lesser curvature. Pathological changes and H pylori infection were determined by HE staining, Alcian blue staining and Giemsa staining.
RESULTS:
The prevalence of H pylori infection was 46.93%. There was no difference in the prevalence between males and females. The prevalence of H pylori infection decreased stepwise significantly from RE grade I to III. There was no difference in the prevalence between the two groups, and between long-segment and short-segment BE. In distal stomach, prevalence of H pylori infection was significantly higher in patients with IM than those without IM.
CONCLUSION:
There is a protective role of H pylori infection to GERD. There may be no relationship between H pylori infection of stomach and BE. H pylori infection is associated with the development of IM in the distal stomach.
AuthorsJun Zhang, Xiao-Li Chen, Kang-Min Wang, Xiao-Dan Guo, Ai-Li Zuo, Jun Gong
JournalWorld journal of gastroenterology (World J Gastroenterol) Vol. 10 Issue 5 Pg. 672-5 (Mar 1 2004) ISSN: 1007-9327 [Print] China
PMID14991936 (Publication Type: Journal Article)
Topics
  • Barrett Esophagus (epidemiology, pathology)
  • China (epidemiology)
  • Female
  • Gastroesophageal Reflux (epidemiology, pathology)
  • Helicobacter Infections (epidemiology, pathology)
  • Helicobacter pylori
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Prospective Studies
  • Sex Distribution

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