Abstract | PURPOSE: METHODS: We performed a systematic review and meta-analysis of randomized controlled trials of the effectiveness of leukotriene receptor antagonists in patients with rhinitis. Composite daily rhinitis symptom scores (as a percentage of the maximum score) and rhinitis-specific quality of life (unit scores ranging from 0 to 6) were pooled after assessing heterogeneity among studies. The pooled estimates were expressed as weighted mean differences between treatments in a random-effects model. We considered a difference of 10% in nasal score and 0.6 units in quality-of-life score to be clinically relevant. RESULTS: CONCLUSION:
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Authors | Andrew M Wilson, Paul M O'Byrne, Krishnan Parameswaran |
Journal | The American journal of medicine
(Am J Med)
Vol. 116
Issue 5
Pg. 338-44
(Mar 01 2004)
ISSN: 0002-9343 [Print] United States |
PMID | 14984820
(Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review, Systematic Review)
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Chemical References |
- Histamine H1 Antagonists
- Leukotriene Antagonists
|
Topics |
- Drug Therapy, Combination
- Histamine H1 Antagonists
(administration & dosage)
- Humans
- Leukotriene Antagonists
(administration & dosage, therapeutic use)
- Rhinitis, Allergic, Perennial
(drug therapy)
- Rhinitis, Allergic, Seasonal
(drug therapy)
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