Abstract |
To examine the effects and optimal dose of danazol on idiopathic thrombocytopenic purpura ( ITP), we administered a low-medium dose to 14 patients with this disease. A low-medium dose of danazol was effective in maintaining the platelet count at a high level, even after the dose of prednisolone was reduced. A low-medium dose of danazol without other therapy was effective in 3 of 6 patients even after they had been refractory to other treatment. A low dose of danazol was also effective in some patients for whom the other regimes were not indicated. It is concluded that a low-medium dose of danazol instead of a high dose is worth trying in ITP when the patient has become refractory to other therapeutic approaches or when these are not indicated.
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Authors | H Kondo, T Iseki, S Goto, T Takaso, M Ohto, K Okuda |
Journal | International journal of hematology
(Int J Hematol)
Vol. 55
Issue 3
Pg. 293-300
(Jun 1992)
ISSN: 0925-5710 [Print] Japan |
PMID | 1498320
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Autoantibodies
- Immunoglobulin G
- Prednisolone
- Danazol
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Topics |
- Adult
- Aged
- Autoantibodies
(immunology)
- Autoimmune Diseases
(drug therapy, surgery, therapy)
- Blood Platelets
(immunology)
- Combined Modality Therapy
- Danazol
(administration & dosage, therapeutic use)
- Female
- Humans
- Immunoglobulin G
(blood)
- Immunosuppression Therapy
- Male
- Middle Aged
- Platelet Count
(drug effects)
- Prednisolone
(therapeutic use)
- Purpura, Thrombocytopenic, Idiopathic
(drug therapy, surgery, therapy)
- Splenectomy
- Treatment Outcome
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