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Efficacy of tilmicosin in the control of experimentally induced Actinobacillus pleuropneumoniae infection in swine.

Abstract
The efficacy of tilmicosin administered in the feed to control Actinobacillus pleuropneumoniae infections in pigs was evaluated through a multisite, multitrial study. For each of 6 trials, 48 pigs (stratified by weight and sex) were randomly assigned to 6 to 8 pens. Medicated feed containing tilmicosin (200 g/t) and unmedicated feed were randomly assigned at the pen level and were provided ad libitum from day -7 to trial termination (day 14). Seeder pigs (inoculated intranasally with A. pleuropneumoniae serotype 1 and showing signs of clinical disease) were introduced to each pen on day 0. Rates of death, gross lesions, and culture of A. pleuropneumoniae at necropsy, clinical scores, average daily gain in weight, and average body temperature were compared between the medicated and unmedicated pigs. Compared with the unmedicated pigs, significantly fewer (P < 0.05) pigs given tilmicosin had lesions typical of A. pleuropneumoniae or had A. pleuropneumoniae isolated from their tissues at necropsy. Together with a significant reduction (P < 0.05) in the average percentage of pneumonic lung involvement (both visually and by weight), there were reductions in the numbers of pigs with moderate and severe pneumonic lung lesions and with A. pleuropneumoniae associated mortality. With tilmicosin treatment, the average daily weight gain, daily temperature, abdominal appearance, attitude, and respiration were also significantly better (P < 0.05). The results of this study demonstrate the in vivo effectiveness of tilmicosin (200 g/t) in controlling pleuropneumonia among swine experimentally infected with A. pleuropneumoniae.
AuthorsMarie-Anne Paradis, Gordon H Vessie, John K Merrill, C Paul Dick, Camille Moore, George Charbonneau, M Gottschalk, Janet I MacInnes, Robert Higgins, K R Mittal, C Girard, Jeffery J Aramini, Jeffrey B Wilson
JournalCanadian journal of veterinary research = Revue canadienne de recherche veterinaire (Can J Vet Res) Vol. 68 Issue 1 Pg. 7-11 (Jan 2004) ISSN: 0830-9000 [Print] Canada
PMID14979429 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • Macrolides
  • tilmicosin
  • Tylosin
Topics
  • Actinobacillus Infections (drug therapy, veterinary)
  • Actinobacillus pleuropneumoniae
  • Administration, Oral
  • Animal Feed
  • Animals
  • Female
  • Macrolides (administration & dosage, therapeutic use)
  • Male
  • Quebec
  • Swine
  • Swine Diseases (drug therapy, pathology)
  • Treatment Outcome
  • Tylosin (administration & dosage, analogs & derivatives, therapeutic use)

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