Abstract |
Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papillomaviruses (HPVs). It is characterized by multiple recurrences of benign neoplasms and has a variable clinical course, ranging from infrequent recurrence to acute airway obstruction. One way in which HPV subverts the immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1). We examined whether a known TAP1 polymorphism in the ATPase domain altered the severity of disease in patients with RRP. The presence of this polymorphism was significantly correlated with severity of disease (P=.015). Because of the proximity of the TAP1 gene to human leukocyte antigen (HLA) class II genes on chromosome 6, we postulated that a linkage disequilibrium may exist. Of the patients with polymorphic TAP1, 36% were positive for HLA-DRB1*0102 (P=.021; P=.147 with Bonferroni's correction). However, this association appeared to mitigate the severity of disease (P=.04). Therefore, severity of disease in a patient with RRP might be determined by sequencing TAP1, in conjunction with HLA class II genes.
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Authors | Andrea Vambutas, Vincent R Bonagura, Elaine F Reed, Allan L Abramson, Virginia Mullooly, James DeVoti, David W Gjertson, Bettie M Steinberg |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 189
Issue 5
Pg. 871-9
(Mar 01 2004)
ISSN: 0022-1899 [Print] United States |
PMID | 14976605
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
- HLA-D Antigens
- HLA-DR Antigens
- HLA-DRB1 Chains
- TAP1 protein, human
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP-Binding Cassette Transporters
(genetics, immunology)
- Chromosomes, Human, Pair 6
(genetics)
- HLA-D Antigens
(genetics)
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Humans
- Major Histocompatibility Complex
- Papillomaviridae
- Papillomavirus Infections
(genetics, immunology, physiopathology)
- Polymorphism, Genetic
- Recurrence
- Severity of Illness Index
- Time Factors
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