HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11.

Abstract
Recurrent respiratory papillomatosis (RRP) is a rare disease caused by human papillomaviruses (HPVs). It is characterized by multiple recurrences of benign neoplasms and has a variable clinical course, ranging from infrequent recurrence to acute airway obstruction. One way in which HPV subverts the immune system in RRP is by interfering with TAP1 (transporter associated with antigen presentation 1). We examined whether a known TAP1 polymorphism in the ATPase domain altered the severity of disease in patients with RRP. The presence of this polymorphism was significantly correlated with severity of disease (P=.015). Because of the proximity of the TAP1 gene to human leukocyte antigen (HLA) class II genes on chromosome 6, we postulated that a linkage disequilibrium may exist. Of the patients with polymorphic TAP1, 36% were positive for HLA-DRB1*0102 (P=.021; P=.147 with Bonferroni's correction). However, this association appeared to mitigate the severity of disease (P=.04). Therefore, severity of disease in a patient with RRP might be determined by sequencing TAP1, in conjunction with HLA class II genes.
AuthorsAndrea Vambutas, Vincent R Bonagura, Elaine F Reed, Allan L Abramson, Virginia Mullooly, James DeVoti, David W Gjertson, Bettie M Steinberg
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 189 Issue 5 Pg. 871-9 (Mar 01 2004) ISSN: 0022-1899 [Print] United States
PMID14976605 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • ATP Binding Cassette Transporter, Subfamily B, Member 2
  • ATP-Binding Cassette Transporters
  • HLA-D Antigens
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • TAP1 protein, human
Topics
  • ATP Binding Cassette Transporter, Subfamily B, Member 2
  • ATP-Binding Cassette Transporters (genetics, immunology)
  • Chromosomes, Human, Pair 6 (genetics)
  • HLA-D Antigens (genetics)
  • HLA-DR Antigens (genetics)
  • HLA-DRB1 Chains
  • Humans
  • Major Histocompatibility Complex
  • Papillomaviridae
  • Papillomavirus Infections (genetics, immunology, physiopathology)
  • Polymorphism, Genetic
  • Recurrence
  • Severity of Illness Index
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: