A new role for C/EBPbeta in acute promyelocytic leukemia.

Abstract

The differentiating properties of retinoic acid (RA) have been used beneficially for the treatment of Acute Promyelocytic Leukemia (APL) for more than a decade. However, the molecular mechanisms of how RA induces APL cell differentiation are still poorly understood. In our previous work, we provided a novel mechanism to explain the unique sensitivity to RA of APL cells. We proposed that C/EBPbeta is an ATRA-dependent PML/RARA target gene and that its activation is critical during ATRA-induced differentiation of APL cells. Here, I discuss how C/EBPbeta could be an important gene in APL pathogenesis.

• Authors: Estelle Duprez
• Journal: Cell cycle (Georgetown, Tex.) (Cell Cycle) Vol. 3 Issue 4 Pg. 389-90 (Apr 2004) ISSN: 1538-4101 [Print] United States
• PMID: 14976428 (Publication Type: Journal Article)

Chemical References

• CCAAT-Enhancer-Binding Protein-beta
• RNA, Messenger
• Tretinoin
• Cyclic AMP

Topics

• CCAAT-Enhancer-Binding Protein-beta (physiology)
• Cell Cycle
• Cell Differentiation
• Cyclic AMP (metabolism)
• Enzyme Activation
• Humans
• Leukemia, Promyelocytic, Acute (metabolism)
• Neoplasms (genetics)
• Oligonucleotide Array Sequence Analysis
• RNA, Messenger (metabolism)
• Signal Transduction
• Transcriptional Activation
• Tretinoin (metabolism)