Usefulness of anti-GQ1b IgG antibody testing in Fisher syndrome compared with cerebrospinal fluid examination.

Abstract

Fisher syndrome (FS), a variant of Guillain-Barré syndrome (GBS), is a rare disorder, and there are few reported studies of a large number of patients with FS. Cerebrospinal fluid (CSF) albuminocytological dissociation was found in 59% of 123 FS patients during the first 3 weeks of illness, while serum anti-GQ1b IgG antibody was positive in 85%. Whereas the incidence of CSF albuminocytological dissociation increased from the first to second weeks in FS, anti-GQ1b IgG antibody peaked in the first week, but there was no CSF albuminocytological dissociation. Statistically, anti-GQ1b antibody testing was superior to a CSF examination in supporting a diagnosis of FS during the first 3 weeks of illness, especially in the first week.

• Authors: Y Nishimoto, M Odaka, K Hirata, N Yuki
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 148 Issue 1-2 Pg. 200-5 (Mar 2004) ISSN: 0165-5728 [Print] Netherlands
• PMID: 14975602 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Albumins
• Antibodies, Anti-Idiotypic
• Gangliosides
• Immunoglobulin G
• GQ1b ganglioside

Topics

• Adolescent
• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Albumins (cerebrospinal fluid)
• Analysis of Variance
• Antibodies, Anti-Idiotypic (blood, cerebrospinal fluid, immunology)
• Child
• Child, Preschool
• Female
• Gangliosides (immunology)
• Guillain-Barre Syndrome (blood, cerebrospinal fluid, diagnosis, immunology)
• Humans
• Immunoglobulin G (blood)
• Infant
• Infant, Newborn
• Male
• Middle Aged
• Miller Fisher Syndrome (blood, cerebrospinal fluid, diagnosis, immunology)
• Statistics, Nonparametric
• Time Factors