Syndecan-1 expression in locally invasive and metastatic prostate cancer.

Abstract

OBJECTIVES:

To determine the significance of syndecan-1 expression, a cell-surface heparan sulfate proteoglycan in localized and metastatic prostate cancer.

METHODS:

We performed a retrospective analysis of 76 men with Gleason sum 6 or 7 prostate cancer treated by radical prostatectomy and a separate cohort of 75 men with metastatic prostate cancer. Syndecan-1 immunoreactivity was measured in primary prostate specimens or in samples from metastatic sites and correlated with patient outcome.

RESULTS:

Syndecan-1 was expressed in normal basal and secretory epithelial cells, 26% of radical prostatectomy specimens, and 35% of metastatic disease. No association was found between syndecan-1 positivity and prostate-specific antigen recurrence in the collective cohort of Gleason sum 6 and 7 cancers. However, when stratified by Gleason sum, syndecan-1 immunoreactivity (immunoreactivity score 150 or greater) was associated with a greater recurrence rate in Gleason sum 7 cancers. Expression of syndecan-1 was significantly greater in soft tissue than in bone metastasis (P = 0.048, Fisher's exact test).

CONCLUSIONS:

Consistent with a possible biochemical role for syndecan-1 in prostate cancer progression and metastasis, syndecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metastases.

• Authors: David Chen, Bosede Adenekan, Lu Chen, E Darracott Vaughan, William Gerald, Ziding Feng, Beatrice S Knudsen
• Journal: Urology (Urology) Vol. 63 Issue 2 Pg. 402-7 (Feb 2004) ISSN: 1527-9995 [Electronic] United States
• PMID: 14972511 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Biomarkers, Tumor
• Membrane Glycoproteins
• Neoplasm Proteins
• Proteoglycans
• SDC1 protein, human
• Syndecan-1
• Syndecans
• Prostate-Specific Antigen

Topics

• Adenocarcinoma (genetics, metabolism, pathology)
• Biomarkers, Tumor (blood)
• Cohort Studies
• Disease-Free Survival
• Humans
• Life Tables
• Male
• Membrane Glycoproteins (biosynthesis, genetics, physiology)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Neoplasm Proteins (biosynthesis, blood, genetics, physiology)
• Prostate-Specific Antigen (blood)
• Prostatic Neoplasms (genetics, metabolism, pathology)
• Proteoglycans (biosynthesis, genetics, physiology)
• Retrospective Studies
• Syndecan-1
• Syndecans