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[The influence of simultaneous pancreas and kidney transplantation on long-term diabetic complications in patients with insulin dependent diabetes mellitus].

Abstract
Diabetic nephropathy affects 20-35% patients with diabetes mellitus. After 25-30 years of nephropathy, chronic renal failure (CRF) develops in these patients. The aim of the study is to present the influence of simultaneous pancreas and kidney transplantation (SPK) on long-term diabetic complications in patients with CRF in course of insulin dependent diabetes mellitus and the length and quality of life of these patients. SPK has positive influence on nerves function of peripheral and autonomic nerve system, as well as heart ventricle function, but brings only limited benefits as regards progression of diabetic retinopathy and nephropathy. The life time of the patients in which SPK was performed is significantly longer that in dialysed patients treated with insulin and patients, in which only cadaveric kidney transplantation was performed. In patients after SPK an improvement of quality of life is also observed. SPK should be considered at the moment of appearance of renal failure symptoms in patients with long lasting insulin dependent diabetes mellitus. Proceeding like this may significantly improve prognosis in this patients, outstandingly disadvantageous if only intermittent dialysis is applied.
AuthorsJacek Ziaja, Wojciech Marcinkowski, Lech Cierpka, Andrzej Wiecek
JournalPolski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 15 Issue 89 Pg. 455-8 (Nov 2003) ISSN: 1426-9686 [Print] Poland
Vernacular TitleWpływ jednoczesnego przeszczepienia trzustki i nerki na odległe powikłania cukrzycy u chorych na cukrzyce insulinozalezna.
PMID14969143 (Publication Type: English Abstract, Journal Article, Review)
Topics
  • Adult
  • Diabetes Mellitus, Type 1 (physiopathology)
  • Humans
  • Kidney Transplantation
  • Pancreas Transplantation
  • Postoperative Complications

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