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Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity.

Abstract
Fatty liver is frequent in the apolipoprotein B (apoB)-defective genetic form of familial hypobetalipoproteinemia (FHBL), but interindividual variability in liver fat is large. To explain this, we assessed the roles of metabolic factors in 32 affected family members with apoB-defective FHBL and 33 related and unrelated normolipidemic controls matched for age, sex, and indices of adiposity. Two hour, 75 g oral glucose tests, with measurements of plasma glucose and insulin levels, body mass index, and waist-hip ratios were obtained. Abdominal subcutaneous, intraperitoneal (IPAT), and retroperitoneal adipose tissue masses were quantified by MR imaging, and hepatic fat was quantified by MR spectroscopy. Mean +/- SD liver fat percentage values of FHBL and controls were 14.8 +/- 12.0 and 5.2 +/- 5.9, respectively (P = 0.001). Means for these measures of obesity and insulin action were similar in the two groups. Important determinants of liver fat percentage were FHBL-affected status, IPAT, and area under the curve (AUC) insulin in both groups, but the strongest predictors were IPAT in FHBL (partial R(2) = 0.55, P < 0.0002) and AUC insulin in controls (partial R(2) = 0.59, P = 0.0001). Regression of liver fat percentage on IPAT fat was significantly greater for FHBL than for controls (P < 0.001). In summary, because apoB-defective FHBL imparts heightened susceptibility to liver triglyceride accumulation, increasing IPAT and insulin resistance exert greater liver fat-increasing effects in FHBL.
AuthorsTariq Tanoli, Pin Yue, Dmitriy Yablonskiy, Gustav Schonfeld
JournalJournal of lipid research (J Lipid Res) Vol. 45 Issue 5 Pg. 941-7 (May 2004) ISSN: 0022-2275 [Print] United States
PMID14967820 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Apolipoproteins B
Topics
  • Adipose Tissue (metabolism, pathology)
  • Adult
  • Apolipoproteins B (genetics, metabolism)
  • Body Mass Index
  • Fatty Liver (complications, metabolism, pathology)
  • Female
  • Glucose Tolerance Test
  • Humans
  • Hypobetalipoproteinemias (complications)
  • Insulin Resistance (physiology)
  • Male
  • Middle Aged
  • Multivariate Analysis

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