Abstract |
An antifungal drug, itraconazole (ITZ) is effective for chromomycosis patients, but the distribution of ITZ and its metabolite, hydroxy-intraconazole ( OH-ITZ) is unclear in pathological tissues. This study investigated how much ITZ and OH-ITZ accumulated in the lesional tissues of chromomycosis and non-lesional skin after oral treatment with ITZ. We determined the concentrations of ITZ and OH-ITZ in the lesional tissues of chromomycosis by Foncecaea pedrosoi and non-lesional skin after oral treatment with a total dose of 2.3g of ITZ. ITZ concentration was significantly higher in pathological skin than non-pathological skin. The ITZ concentration in the lesional tissues was higher in the central site than in the marginal site. No difference was seen in the OH-ITZ concentrations among three skin parts, the center and the margin in lesional skin, and non-lesional skin adjacent to the lesion. This study showed higher concentrations of ITZ in pathological tissues than in non-pathological tissues.
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Authors | Mariko Seishima, Zuiei Oyama, Makiko Oda, Shiomi Ishigo |
Journal | European journal of dermatology : EJD
(Eur J Dermatol)
2004 Jan-Feb
Vol. 14
Issue 1
Pg. 24-7
ISSN: 1167-1122 [Print] France |
PMID | 14965791
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright John Libbey Eurotext 2003. |
Chemical References |
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Topics |
- Administration, Oral
- Biological Availability
- Biopsy, Needle
- Chromoblastomycosis
(drug therapy, pathology)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Follow-Up Studies
- Humans
- Immunohistochemistry
- Itraconazole
(administration & dosage, pharmacokinetics)
- Male
- Middle Aged
- Treatment Outcome
- Trichophyton
(isolation & purification)
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