HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Distribution of an antifungal drug, itraconazole, in pathological and non-pathological tissues.

Abstract
An antifungal drug, itraconazole (ITZ) is effective for chromomycosis patients, but the distribution of ITZ and its metabolite, hydroxy-intraconazole (OH-ITZ) is unclear in pathological tissues. This study investigated how much ITZ and OH-ITZ accumulated in the lesional tissues of chromomycosis and non-lesional skin after oral treatment with ITZ. We determined the concentrations of ITZ and OH-ITZ in the lesional tissues of chromomycosis by Foncecaea pedrosoi and non-lesional skin after oral treatment with a total dose of 2.3g of ITZ. ITZ concentration was significantly higher in pathological skin than non-pathological skin. The ITZ concentration in the lesional tissues was higher in the central site than in the marginal site. No difference was seen in the OH-ITZ concentrations among three skin parts, the center and the margin in lesional skin, and non-lesional skin adjacent to the lesion. This study showed higher concentrations of ITZ in pathological tissues than in non-pathological tissues.
AuthorsMariko Seishima, Zuiei Oyama, Makiko Oda, Shiomi Ishigo
JournalEuropean journal of dermatology : EJD (Eur J Dermatol) 2004 Jan-Feb Vol. 14 Issue 1 Pg. 24-7 ISSN: 1167-1122 [Print] France
PMID14965791 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright John Libbey Eurotext 2003.
Chemical References
  • Itraconazole
Topics
  • Administration, Oral
  • Biological Availability
  • Biopsy, Needle
  • Chromoblastomycosis (drug therapy, pathology)
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Itraconazole (administration & dosage, pharmacokinetics)
  • Male
  • Middle Aged
  • Treatment Outcome
  • Trichophyton (isolation & purification)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: