Efficacy and tolerability of flupenthixol decanoate in the treatment of depression and psychosomatic disorders: a multicenter trial in general practice.

Abstract

1. A number of controlled as well as uncontrolled studies indicate that flupenthixol in a low-dose regimen is effective in treating syndromes with depression, anxiety, and psychosomatic disorders. 2. In view of the low compliance rates among patients suffering from depressive syndromes, the author evaluated the efficacy and tolerability of flupenthixol decanoate i.m. in an unselected collective of such patients treated in general practices. 3. Flupenthixol decanoate i.m. induced remission in 25% of patients suffering from chronic pain, in 29% of patients with psychosomatic disorders. Patients with depression and anxiety remitted in 27% of the cases. Therapeutic benefit was seen in more than 90% of the patients. 4. The best results were observed in patients 1) who had not been treated with psychotropic drugs before, 2) whose disease had a duration of less than one year, 3) who were under 40 years of age, and 4) who were treated with a dose lower than 0.5 ml (10 mg flupenthixol decanoate).

• Authors: G Budde
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 16 Issue 5 Pg. 677-89 (Sep 1992) ISSN: 0278-5846 [Print] England
• PMID: 1496124 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Tranquilizing Agents
• flupenthixol decanoate
• Flupenthixol

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Depression (drug therapy)
• Drug Tolerance
• Family Practice
• Female
• Flupenthixol (adverse effects, analogs & derivatives, therapeutic use)
• Humans
• Male
• Middle Aged
• Psychophysiologic Disorders (drug therapy)
• Tranquilizing Agents (adverse effects, therapeutic use)