Ranitidine and sodium citrate as prophylaxis against acid aspiration syndrome in obstetric patients undergoing caesarean section.

The efficacy of a single oral dose of 0.3M of sodium citrate alone as a prophylaxis against acid aspiration syndrome in obstetric patients undergoing LSCS (elective and emergency) was compared with that of intravenous ranitidine. One group of patients was given 30 ml of 0.3M sodium citrate orally just before the induction of anaesthesia while the other group was given 50mg of ranitidine intravenously together with the 30ml of 0.3M sodium citrate. This was done for both the elective and the emergency groups of patients. There was no significant difference in the mean pH of the gastric aspirate obtained from those given sodium citrate alone and those given sodium citrate and ranitidine in either the elective or the emergency group. However, in the emergency group, those who were given sodium citrate alone tend to have a larger volume of gastric aspiration when compared with those given ranitidine together with the sodium citrate. There were significantly more patients with gastric aspirates of more than 25ml in the emergency group to which sodium citrate alone was given. It would appear that supplementing an intravenous dose of ranitidine with the oral dose of sodium citrate is useful in emergency LSCS as a prophylaxis against acid aspiration syndrome.
AuthorsS K Lim, E O Elegbe
JournalSingapore medical journal (Singapore Med J) Vol. 33 Issue 6 Pg. 608-10 (Dec 1992) ISSN: 0037-5675 [Print] SINGAPORE
PMID1488672 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antacids
  • Citrates
  • Citric Acid
  • Ranitidine
  • Adult
  • Antacids (administration & dosage)
  • Cesarean Section
  • Citrates (administration & dosage)
  • Citric Acid
  • Female
  • Humans
  • Pneumonia, Aspiration (prevention & control)
  • Pregnancy
  • Premedication
  • Ranitidine (administration & dosage)

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