Abstract | OBJECTIVE: METHODS: Eighteen adult mongrel dogs, weight 22.6(SD 1.1) kg, anaesthetised with sodium pentobarbitone, were used for the study. The left anterior descending coronary artery was ligated for 60 min and then reperfused for 30 min. Saralasin (60 micrograms.kg-1, n = 9) or its vehicle (Ringer lactate, n = 9) was injected into the artery at the beginning of the occlusion period. Two epicardial veins, one running parallel to the left anterior descending coronary artery and the other parallel to the circumflex coronary artery, were cannulated for the measurement of their respective blood flows and of noradrenaline, lactate, and creatine kinase release. RESULTS: CONCLUSIONS: Intracoronary saralasin in the early phase of myocardial ischaemia increases the epicardial venous blood flow significantly, suggesting that angiotensin II is implicated in coronary constriction during ischaemia. This haemodynamic effect is accompanied by a significant decrease in the incidence of ventricular fibrillation. However, the renin-angiotensin system does not appear to be implicated in the reperfusion induced noradrenaline release nor in the incidence of the ventricular arrhythmias.
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Authors | C Ribuot, N Yamaguchi, D Godin, L Jetté, R Nadeau |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 26
Issue 10
Pg. 968-72
(Oct 1992)
ISSN: 0008-6363 [Print] England |
PMID | 1486590
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lactates
- Lactic Acid
- Creatine Kinase
- Saralasin
- Norepinephrine
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Topics |
- Animals
- Arrhythmias, Cardiac
(etiology, metabolism)
- Coronary Vessels
(drug effects)
- Creatine Kinase
(biosynthesis)
- Dogs
- Female
- Heart
(drug effects)
- Lactates
(biosynthesis)
- Lactic Acid
- Male
- Myocardial Reperfusion Injury
(complications, metabolism)
- Myocardium
(metabolism)
- Norepinephrine
(biosynthesis)
- Saralasin
(pharmacology)
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