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[Changes in the mechanism of action of insulin on fatty tissue accumulations in lipomas, Madelung's lipomatosis and liposarcoma].

Abstract
In this paper, the preliminary results regarding the alterations of the biological action mechanism of insulin in several types of pathological accumulations of fat, i.e. lipomas, Madelung's Lipomatosis and liposarcoma, are presented. The results indicate significant alterations both at the insulin receptor and post-receptor levels, with reduced biological activity of this hormone, which could have and inductive role in the pathogenesis of such entities.
AuthorsM C Carranza, M A Simón, A Torres, B Romero, C Calle
JournalAnales de medicina interna (Madrid, Spain : 1984) (An Med Interna) Vol. 9 Issue 12 Pg. 598-602 (Dec 1992) ISSN: 0212-7199 [Print] Spain
Vernacular TitleAlteraciones en el mecanismo de acción de la insulina en los acúmulos de tejido adiposo de lipomas, lipomatosis de Madelung y liposarcoma.
PMID1486167 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Insulin
  • Receptor, Insulin
Topics
  • Adipose Tissue (drug effects, metabolism)
  • Adult
  • Female
  • Humans
  • Insulin (pharmacokinetics, pharmacology)
  • Lipoma (etiology, metabolism)
  • Lipomatosis, Multiple Symmetrical (etiology, metabolism)
  • Liposarcoma (etiology, metabolism)
  • Male
  • Middle Aged
  • Receptor, Insulin (drug effects, metabolism)
  • Retroperitoneal Neoplasms (etiology, metabolism)
  • Skin Neoplasms (etiology, metabolism)

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