Topical ofloxacin compared with gentamicin in the treatment of external ocular infection. Ofloxacin Study Group.

Abstract

In a double-masked, randomised, controlled study the effectiveness and safety of 0.3% ofloxacin solution were compared with those of 0.3% gentamicin ophthalmic solution in treating external bacterial ocular infections. The clinical improvement rate for patients treated with ofloxacin was 98% (51/52) and 92% (48/52) for those treated with gentamicin. Microbiological improvement was achieved in 78% (40/51) of the ofloxacin patients, compared with 67% (35/52) of the gentamicin group. Ofloxacin treatment eradicated or controlled 85% (86/101) of the Gram positive and 89% (17/19) of the Gram negative organisms cultured, compared with 83% (103/124) and 78% (29/37), respectively, after gentamicin treatment. None of these differences were statistically significant. The incidence of adverse effects attributable to ofloxacin treatment (3.2%) was less than that reported for gentamicin (7.1%). Ofloxacin proved to be an effective, safe, and comfortable therapy for external bacterial ocular infection.

• Authors: A Gwon
• Journal: The British journal of ophthalmology (Br J Ophthalmol) Vol. 76 Issue 12 Pg. 714-8 (Dec 1992) ISSN: 0007-1161 [Print] England
• PMID: 1486071 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Gentamicins
• Ophthalmic Solutions
• Ofloxacin

Topics

• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Blepharitis (drug therapy)
• Conjunctivitis (drug therapy)
• Eye Infections, Bacterial (drug therapy)
• Female
• Gentamicins (administration & dosage)
• Humans
• Male
• Middle Aged
• Ofloxacin (administration & dosage)
• Ophthalmic Solutions