Generation of mutant mice lacking surface expression of CD4 or CD8 gene targeting.

Abstract

With the use of homologous recombination in embryonic stem cells, two new strains of mice lacking surface CD4 or CD8 expression have been generated. It is hoped that they will be useful mouse strains for the study of autoimmune diseases, tissue transplantation rejections and tumour rejections.

• Authors: T W Mak, A Rahemtulla, M Schilham, D R Koh, W P Fung-Leung
• Journal: Advances in experimental medicine and biology (Adv Exp Med Biol) Vol. 323 Pg. 73-7 ( 1992) ISSN: 0065-2598 [Print] United States
• PMID: 1485566 (Publication Type: Journal Article, Review)

Chemical References

• Antigens, Ly
• CD4 Antigens
• CD8 Antigens

Topics

• Animals
• Antigens, Ly (biosynthesis, genetics)
• Autoimmune Diseases
• CD4 Antigens (biosynthesis, genetics)
• CD8 Antigens (biosynthesis, genetics)
• Disease Models, Animal
• Exons
• Gene Expression Regulation
• Immunity, Cellular
• Mice (embryology)
• Mice, Mutant Strains (genetics, immunology)
• Mutagenesis, Insertional
• Recombination, Genetic
• Stem Cells
• Transplantation Immunology