Comparative effect of fasting on acetoacetate and D-3-hydroxybutyrate metabolism in the newborn chick.
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| Abstract |
The effect of 24 h fasting on ketone body utilization by three extranervous tissues, liver, duodenum and kidney, was studied in two critical ages of neonatal chick: 4 and 9 days. In 4-day-old chick, plasma concentration of 3-hydroxybutyrate increased about 9-fold after 24 h starvation, while in 9-day-old chick this parameter increased about 23-fold in the same conditions. Hepatic lipogenesis from both precursors sharply decreased by fasting. Changes in the lipogenic activity of duodenum were less patent. However, we have found a clear increase in lipogenesis in chick kidney after 24 h starvation. CO2 production from acetoacetate was higher than that found from hydroxybutyrate. No significant differences in the acetoacetate oxidation to CO2 was observed in any tissue assayed after 24 h fasting. 14C incorporation from ketone bodies into amino acids was clearly decreased in kidney from 9-day-old chick by fasting. In liver and duodenum, acetoacetate incorporation into amino acids was higher than that from hydroxybutyrate.
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| Authors | A Linares, R Diaz, G J Caamaño, F J Gonzalez, E Garcia-Peregrin |
| Journal | Biochemistry international (Biochem Int) Vol. 28 Issue 4 Pg. 683-91 (Dec 1992) ISSN: 0158-5231 [Print] Australia |
| PMID | 1482404 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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