Abstract |
Severe anaphylactic or allergic reactions may occur during blood transfusion to patients who are IgA-deficient and have anti-IgA in their blood, particularly those with class-specific antibodies. These patients are a particular challenge to the hospital transfusion service when large volumes of blood components are required for transfusion support, as in liver transplantation. We have successfully provided blood components for 3 such patients undergoing liver transplantation. Red cells were washed manually or by automated technique. Platelets were washed manually. All plasma was from IgA-deficient donors. One patient's entire plasma requirements were supplied by autologous plasmapheresis. Serial determinations of IgA levels and anti-IgA titers in 1 patient demonstrated an abrupt fall in anti-IgA with the appearance of barely detectable amounts of IgA during the surgery. IgA-containing plasma cells were demonstrated in the biopsies of liver homografts of 2 patients following transplantation. IgA deficiency with anti-IgA can be successfully managed during liver transplantation with advance planning.
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Authors | R D Davenport, K L Burnie, R M Barr |
Journal | Vox sanguinis
(Vox Sang)
Vol. 63
Issue 4
Pg. 247-50
( 1992)
ISSN: 0042-9007 [Print] England |
PMID | 1481472
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Autoantibodies
- Blood Transfusion
(methods)
- Erythrocytes
- Female
- Humans
- IgA Deficiency
(therapy)
- Liver Transplantation
- Male
- Middle Aged
- Plasmapheresis
- Transfusion Reaction
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