The acute phase response in autologous bone marrow transplantation.

Abstract

Due to the stress imposed by the process of bone marrow transplantation (BMT), we hypothesized that individuals receiving such a transplant underwent an acute phase response (APR). Circulating levels of C-reactive protein (CRP), haptoglobin (HAP), alpha-1 acid glycoprotein (AAG), ceruloplasmin (CER), zinc (Zn), copper (Cu), interleukin-6 (IL-6), albumin (ALB), and thyroxine-binding prealbumin (TBPA), were measured at baseline (Day -7), Day -4, Day 0 (Transplant Day), Day +2, +7, and weekly until day 28 in 14 adults receiving an autologous bone marrow transplant as Phase 1 treatment for various hematologic or solid tumor malignancies. Ten of 14 recipients survived, 9 of which had a significant increase in CRP (p = 0.012), HAP (p = 0.011), AAG (p = 0.002), and decrease in ALB (p = 0.002) and TBPA (p = 0.004) on Day +7, but not Day 0, after bone marrow reinfusion. These findings document the presence of an APR and suggest that the bone marrow transplant process (post reinfusion) initiates a stress response in the recipient.

• Authors: M G Boosalis, D Gray, S Walker, S Sutliff, R Talwalker, A Mazumder
• Journal: Journal of medicine (J Med) Vol. 23 Issue 3-4 Pg. 175-93 ( 1992) ISSN: 0025-7850 [Print] United States
• PMID: 1479299 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Haptoglobins
• Interleukin-6
• Orosomucoid
• Serum Albumin
• Thyroxine-Binding Proteins
• Copper
• C-Reactive Protein
• Ceruloplasmin
• Zinc

Topics

• Acute-Phase Reaction (blood, etiology, pathology)
• Adult
• Biomarkers
• Body Weight
• Bone Marrow Transplantation (adverse effects, pathology)
• C-Reactive Protein (metabolism)
• Ceruloplasmin (metabolism)
• Copper (blood)
• Female
• Haptoglobins (metabolism)
• Humans
• Interleukin-6 (blood)
• Male
• Middle Aged
• Orosomucoid (metabolism)
• Serum Albumin (metabolism)
• Thyroxine-Binding Proteins (metabolism)
• Transplantation, Autologous
• Zinc (blood)