Abstract | BACKGROUND: The treatment of Bowen's disease in anatomically difficult areas or especially large lesions can challenge accepted modalities of treatment. OBJECTIVE: METHODS: Six patients with Bowen's disease in various anatomic sites were treated with photodynamic therapy. Four were in a difficult anatomic site, or were especially large, or both. Photofrin, 1.0 mg/kg, was administered intravenously and laser treatment was given approximately 48 hours later with the argon dye laser. Light was administered at a wavelength of 630 nm and the light dose ranged from 185 to 250 joules/cm2. Treatment was given by surface radiation only. RESULTS: Eight lesions were treated. All showed a complete response at 3 months (100%) and continue to show a complete response at 6 and 12 months. Morbidity was low; the most significant side effects were moderate pain and edema. Healing time varied depending on the size of the lesion. CONCLUSION:
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Authors | C M Jones, T Mang, M Cooper, B D Wilson, H L Stoll Jr |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 27
Issue 6 Pt 1
Pg. 979-82
(Dec 1992)
ISSN: 0190-9622 [Print] United States |
PMID | 1479105
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Bowen's Disease
(drug therapy, pathology)
- Female
- Humans
- Male
- Middle Aged
- Photochemotherapy
- Skin Neoplasms
(drug therapy, pathology)
- Treatment Outcome
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