Abstract | PURPOSE: METHODS: We studied 106 eyes of 53 type II DM patients without proliferative diabetic retinopathy and panretinal photocoagulation. All underwent standard ophthalmic examinations, color Doppler imaging, and serum ALB measurements. The patients were divided into Group 1 (34 cases) with a serum ALB > or =3.8 g/dl and Group 2 (19 cases) with ALB<3.8 g/dl. RESULTS: All of the optic disks appeared normal by Ophthalmoscopy except one case with the lowest serum ALB. The number of optic disks showing late fluorescein staining was significantly higher in Group 2 than in Group 1. Peak systolic velocities in the central retinal artery (CRA, P=0.02) and central retinal vein (CRV, P<0.001) were significantly higher in Group 2, and significantly correlated with the serum ALB value (CRA; r=0.41, P=0.003 and CRV; r=0.60, P<0.001). CONCLUSIONS: We suggest that low serum ALB enhances the permeability of the vessels in or around the optic disk and induces subclinical optic disk edema, which is characterized by late fluorescein staining and high blood flow velocities in the CRA and CRV.
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Authors | Sayuri Fujioka, Kaoruko Karashima, Norikiyo Nishikawa, Yoshihiro Saito |
Journal | Japanese journal of ophthalmology
(Jpn J Ophthalmol)
2004 Jan-Feb
Vol. 48
Issue 1
Pg. 59-64
ISSN: 0021-5155 [Print] Japan |
PMID | 14767653
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Blood Flow Velocity
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(blood, physiopathology)
- Diabetic Retinopathy
(blood, physiopathology)
- Female
- Fluorescein Angiography
- Humans
- Male
- Middle Aged
- Ophthalmic Artery
(diagnostic imaging, physiology)
- Optic Disk
(blood supply)
- Papilledema
(blood, physiopathology)
- Regional Blood Flow
- Retinal Artery
(diagnostic imaging, physiology)
- Retinal Vein
(diagnostic imaging, physiology)
- Serum Albumin
(metabolism)
- Ultrasonography, Doppler, Color
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