Successful unrelated cord blood transplantation following reduced-intensity conditioning for refractory acute myeloid leukemia.

Abstract

Patients with relapsed acute myeloid leukemia following autograft have a poor prognosis. The possibility of allograft is frequently time-limited, as the disease reappears before a stem cell donor can be found in the worldwide registries. Cord blood transplantation is a new therapeutic approach, since cord blood units are rapidly available. The authors show how a relapsed chemotherapy-refractory patient was successful transplanted with a mismatched cord blood unit after reduced-intensity conditioning. Twenty-three months after transplantation, the child is in continuous complete remission and has full donor chimerism and no signs of chronic graft-versus-host disease.

• Authors: Massimo Berger, Elena Vassallo, Francesca Nesi, Claudio Venturi, Enrico Madon, Franca Fagioli
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 26 Issue 2 Pg. 98-100 (Feb 2004) ISSN: 1077-4114 [Print] United States
• PMID: 14767195 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child, Preschool
• Cord Blood Stem Cell Transplantation
• Graft vs Host Disease (prevention & control)
• Graft vs Leukemia Effect (immunology)
• Humans
• Leukemia, Myelomonocytic, Acute (therapy)
• Male
• Neoplasm Recurrence, Local (therapy)
• Remission Induction
• Transplantation Conditioning
• Treatment Outcome