Abstract | BACKGROUND & AIMS: METHODS: We collected data and tumors on 204 consecutive stage II and III colorectal cancer patients from registries at the University of California and Veterans Administration hospitals in San Diego, California, from 1982 to 1999. Archival DNA was extracted, and microsatellite instability was assessed by National Cancer Institute-recommended markers. Cox proportional hazard modeling was used to determine survival associations for microsatellite instability and 5-fluorouracil treatment status. RESULTS: CONCLUSIONS:
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Authors | John M Carethers, E Julieta Smith, Cynthia A Behling, Lanchinh Nguyen, Akihiro Tajima, Ryan T Doctolero, Betty L Cabrera, Ajay Goel, Christian A Arnold, Katsumi Miyai, C Richard Boland |
Journal | Gastroenterology
(Gastroenterology)
Vol. 126
Issue 2
Pg. 394-401
(Feb 2004)
ISSN: 0016-5085 [Print] United States |
PMID | 14762775
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimetabolites, Antineoplastic
- Genetic Markers
- Fluorouracil
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Topics |
- Aged
- Antimetabolites, Antineoplastic
(therapeutic use)
- Cohort Studies
- Colorectal Neoplasms
(drug therapy, genetics, pathology)
- Female
- Fluorouracil
(therapeutic use)
- Genetic Markers
- Humans
- Male
- Microsatellite Repeats
(genetics)
- Middle Aged
- Neoplasm Staging
- Proportional Hazards Models
- Registries
- Survival Analysis
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