Abstract | PURPOSE:
Moesin is a linking protein of the submembraneous cytoskeleton and plays a key role in the control of cell morphology, adhesion, and motility. The aim of the present study was to elucidate the clinical significance of expression patterns of moesin in patients with oral squamous cell carcinoma (OSCC). EXPERIMENTAL DESIGN: RESULTS: Expression patterns of moesin in OSCCs were divided into three groups: membranous pattern; mixed pattern; and cytoplasmic pattern. These expression patterns correlated with tumor size, lymph node metastasis, mode of invasion, differentiation, and lymphocytic infiltration. In about two-thirds of the patients with metastatic lymph node, homogeneous cytoplasmic expression was detected in the metastatic lymph nodes. In addition, SQUU-B with high metastatic potential showed more reduced levels of membrane-bound moesin than SQUU-A with low metastatic potential. A multivariate analysis demonstrated that expression patterns of moesin can be an independent prognostic factor. CONCLUSIONS: Our results suggest that moesin expression contributed to discriminating between patients with the potentiality for locoregional lymph node metastasis and those with a better prognosis and might improve the definition of suitable therapy for each.
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Authors | Hiroichi Kobayashi, Junji Sagara, Hiroshi Kurita, Masayo Morifuji, Masamichi Ohishi, Kenji Kurashina, Shun'ichiro Taniguchi |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 10
Issue 2
Pg. 572-80
(Jan 15 2004)
ISSN: 1078-0432 [Print] United States |
PMID | 14760079
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Microfilament Proteins
- moesin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibodies, Monoclonal
- Carcinoma, Squamous Cell
(metabolism, pathology)
- Cell Adhesion
- Cell Line, Tumor
- Cell Movement
- Cytoplasm
(metabolism)
- Epithelium
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Male
- Mice
- Mice, Inbred BALB C
- Microfilament Proteins
(biosynthesis, metabolism)
- Middle Aged
- Mouth Neoplasms
(metabolism, pathology)
- Multivariate Analysis
- Neoplasm Metastasis
- Prognosis
- Time Factors
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